Effect of sertraline on the recovery rate of cardiac autonomic function in depressed patients after acute myocardial infarction.
نویسندگان
چکیده
BACKGROUND Brain serotonin is known to possess sympathoinhibitory properties. The aim of this clinical physiologic study was to determine whether sertraline, a selective serotonin reuptake inhibitor, facilitates the rate of recovery of cardiac autonomic function after an acute myocardial infarction (MI) in patients with depression. METHODS AND RESULTS Thirty-eight post-MI depressed patients were randomized to receive either sertraline 50 mg per day or placebo for 6 months. Depression was defined as a score >15 on the standardized Inventory to Diagnose Depression questionnaire taken at prehospital discharge and again within 2 weeks of the acute infarct. Eleven stable post-MI nondepressed patients served as a nonrandomized reference group during follow-up. Twenty-seven patients completed the randomization. All 3 groups were followed up closely in a multidisciplinary post-MI clinic where they underwent serial testing for both time and frequency domain heart rate variability (HRV) indices at baseline (1-2 weeks after MI) and at 6, 10, 14, 18, and 22 weeks. The rate of recovery of HRV was determined by use of a growth curve model based on repeated-measures analysis of variance. There was a linear rate of increase in the SD of 24-hour N-N intervals (SDNN) in the sertraline-treated group that paralleled that of the nondepressed reference group. This contrasted with a modest but significant decline in SDNN in the placebo group from 2 to 22 weeks (t = 2.10, P <.05). However, the short-term power spectral indices, while trending toward a more rapid rate of recovery in the treated group, did not reach statistical significance compared with the placebo group. CONCLUSION In depressed patients who have survived the acute phase of an MI sertraline facilitates the rate of recovery of SDNN, a recognized predictor of clinical outcome.
منابع مشابه
Prediction of long-term cardiac events by 123I-MIBG imaging after acute myocardial infarction and reperfusion therapy
Objective(s): In heart failure, the heart-to-mediastinum (H/M) ratio of the delayed image and washout rate (WR) are well-known as a powerful cardiac event predictors. H/M ratio quantifies the accumulation rate of MIBG in the myocardium and WR quantifies reduction of meta-iodobenzylguanidine (MIBG) accumulation in the heart from the early planar image to the delayed pla...
متن کاملThe Effect of Opium Addiction on Cardiac Arrhythmia after Acute Myocardial Infarction
Background & Aims: This study was carried out to assess the effect of opium addiction on the incidence of different types of arrhythmias after acute myocardial infarction (AMI). Methods: The study population consisted of 200 patients with first AMI admitted within 6 hours of the onset of chest pain to the coronary care units (CCU) of two hospitals affiliated to Kerman University of Medical Scie...
متن کاملEffect of Cardiac Rehabilitation on Heart Rate and Functional Capacity in Patients After Myocardial Infarction
Objectives: The primary purpose of this study was to determine the methods and means of prevention and treatment of coronary artery disease. In this study, we used a new regimen on heart rate and functional capacity of patients after myocardial infarction. This study also determines the effect of a new regimen on these factors. Methods: The cross sectional study was designed to assess the clin...
متن کاملThe effect of oxygen inhalation on cardiac biomarkers in patients presenting with acute ST-segment elevation myocardial infraction: A randomized clinical trial
Background: It is assumed giving oxygen to patients with acute myocardial infraction may increase the oxygenation of the ischemic tissue; however, the usefulness of oxygen in these patients has become a challenging topic. Thus, the present study aimed to determine the effect of oxygen inhalation on cardiac biomarkers in patients with acute myocardial infarction. Methods: This randomized cli...
متن کاملA comparison of the effect of training by peers and nurses on anxiety in patients with myocardial infarction: A randomized control trial
Background and Objectives: Anxiety is one of the most common psychological reactions in patients with acute myocardial infarction. This study aimed to compare the effect of training by peers and nurses on anxiety in patients with acute myocardial infarction. Materials and Methods: This study is a quasi-experimental intervention. Samples included 60 patients with myocardial infarction who wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American heart journal
دوره 142 4 شماره
صفحات -
تاریخ انتشار 2001